The Shear Wave Liver Fibrosis Phantoms provide a set of reference standards for performing quantitative measurements of tissue stiffness, and is compatible with the main ultrasound shear wave modalities including Fibroscan's Vibration Controlled Transient Elastography (VCTE
TM), Supersonic Imagine's Shear Wave elasticity imaging, and Acoustic Radiation Force Impulse (ARFI) elastography. Shear wave elasticity imaging is an emerging biomarker with many possible applications, most prominently for determining the stage of liver fibrosis in a patient without the need for invasive biopsies.
Model 039 includes four separate phantoms of varying stiffness: 3, 12, 27, and 48 kPa. The elasticity of the phantoms was chosen based on average tissue elasticty at various stages of liver fibrosis. Stiffness of 3 kPa represents elasticity of healthy tissue, while 48 kPa represents elasticity of tissue with stage-five liver fibrosis. Phantoms can also be manufactured according to user requirements with custom stiffness ranging from 1 to 100 kPa.
Certification of Young’s modulus will be provided with each phantom for proof of measurements with a precision of +/- 4%. Young’s modulus is tested on batch samples following ASTM standard D575-91 to ensure accurate elasticity. Density will also be measured to allow accurate conversion of shear wave speed to shear wave modulus and Young’s modulus.